| RRC ID |
74111
|
| Author |
Katsuma S, Hirota K, Matsuda-Imai N, Fukui T, Muro T, Nishino K, Kosako H, Shoji K, Takanashi H, Fujii T, Arimura SI, Kiuchi T.
|
| Title |
A Wolbachia factor for male killing in lepidopteran insects.
|
| Journal |
Nat Commun
|
| Abstract |
Bacterial symbionts, such as Wolbachia species, can manipulate the sexual development and reproduction of their insect hosts. For example, Wolbachia infection induces male-specific death in the Asian corn borer Ostrinia furnacalis by targeting the host factor Masculinizer (Masc), an essential protein for masculinization and dosage compensation in lepidopteran insects. Here we identify a Wolbachia protein, designated Oscar, which interacts with Masc via its ankyrin repeats. Embryonic expression of Oscar inhibits Masc-induced masculinization and leads to male killing in two lepidopteran insects, O. furnacalis and the silkworm Bombyx mori. Our study identifies a mechanism by which Wolbachia induce male killing of host progeny.
|
| Volume |
13(1)
|
| Pages |
6764
|
| Published |
2022-11-14
|
| DOI |
10.1038/s41467-022-34488-y
|
| PII |
10.1038/s41467-022-34488-y
|
| PMID |
36376299
|
| PMC |
PMC9663696
|
| MeSH |
Animals
Bombyx* / genetics
Bombyx* / metabolism
Dosage Compensation, Genetic
Insect Proteins / genetics
Insect Proteins / metabolism
Male
Moths* / microbiology
Wolbachia* / metabolism
|
| IF |
12.121
|
| Resource |
| Silkworms |
p50 |
