論文 - 詳細
| RRC ID | 74222 |
|---|---|
| 著者 | Takumi Sugioka, Masashi Tanimoto, Shin-ichi Higashijima |
| タイトル | Biomechanics and neural circuits for vestibular-induced fine postural control in larval zebrafish |
| ジャーナル | Nature Communications |
| Abstract |
Land-walking vertebrates maintain a desirable posture by finely controlling muscles. It is unclear whether fish also finely control posture in the water. Here, we showed that larval zebrafish have fine posture control. When roll-tilted, fish recovered their upright posture using a reflex behavior, which was a slight body bend near the swim bladder. The vestibular-induced body bend produces a misalignment between gravity and buoyancy, generating a moment of force that recovers the upright posture. We identified the neural circuits for the reflex, including the vestibular nucleus (tangential nucleus) through reticulospinal neurons (neurons in the nucleus of the medial longitudinal fasciculus) to the spinal cord, and finally to the posterior hypaxial muscles, a special class of muscles near the swim bladder. These results suggest that fish maintain a dorsal-up posture by frequently performing the body bend reflex and demonstrate that the reticulospinal pathway plays a critical role in fine postural control. |
| 巻・号 | 14 |
| 公開日 | 2023-3-10 |
| DOI | 10.1038/s41467-023-36682-y |
| PMID | 36898983 |
| PMC | PMC10006170 |
| MeSH | Animals Biomechanical Phenomena Larva Neurons* / physiology Postural Balance / physiology Spinal Cord / physiology Zebrafish* / physiology |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 12 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(evx2-hs:GFP) Tg(evx2-hs:tdTomato-jGCaMP7b) Tg(evx2-hs:CoChR-GFP) Tg(pitx2-hs:Dendra2) Tg(smyhc2-hs:tdTomato-jGCaMP7b) Tg(smyhc2-hs:lRl-DTA) |