論文 - 詳細
| RRC ID | 74260 |
|---|---|
| 著者 | Takamatsu A, Yaguchi T, Tagashira Y, Watanabe A, Honda H, Japan Nocardia Study Group. |
| タイトル | Nocardiosis in Japan: a Multicentric Retrospective Cohort Study. |
| ジャーナル | Antimicrob Agents Chemother |
| Abstract |
Nocardia species cause a broad spectrum of infections, especially in immunocompromised patients. Given its relative rarity, data on the prognosis and distribution of nocardiosis from a large cohort are scarce. The present study aimed to scrutinize the clinical features and outcomes of nocardiosis in Japan, including 1-year mortality and microbiological data. The present multicentric, retrospective cohort study enrolled patients aged ≥18 years with nocardiosis diagnosed between January 2010 and December 2017 and recorded their clinical and microbiological characteristics. Factors associated with 1-year mortality were also determined using Cox proportional hazard analysis. In total, 317 patients were identified at 89 hospitals. Almost half (155/317, 48.9%) were receiving immunosuppressive agents, and 51 had disseminated nocardiosis (51/317, 16.1%). The 1-year all-cause mortality rate was 29.4% (80/272; lost to follow-up, n = 45). The most frequently isolated species was Nocardia farcinica (79/317, 24.9%) followed by the Nocardia nova complex (61/317, 19.2%). Selected antimicrobial agents were generally effective, with linezolid (100% susceptibility [S]) and amikacin (94% S) having the most activity against Nocardia species. In Cox proportional hazard analysis, factors independently associated with 1-year mortality were a Charlson comorbidity index score of ≥5 (adjusted hazard ratio [aHR], 3.61; 95% confidence interval [CI], 1.95 to 6.71, P < 0.001) and disseminated nocardiosis (aHR, 1.79; 95%CI, 1.01 to 3.18, P = 0.047). The presence of advanced comorbidities and disseminated infection, rather than variations in antimicrobial therapy or Nocardia species, was independently associated with 1-year mortality. |
| 巻・号 | 66(2) |
| ページ | e0189021 |
| 公開日 | 2022-2-15 |
| DOI | 10.1128/AAC.01890-21 |
| PMID | 34902263 |
| PMC | PMC8942482 |
| MeSH | Adolescent Adult Anti-Bacterial Agents / therapeutic use Cohort Studies Humans Japan / epidemiology Nocardia* Nocardia Infections* / drug therapy Nocardia Infections* / microbiology Retrospective Studies |
| IF | 4.904 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 病原真核微生物 | Nocardia spp. IFM 317 strains |