RRC ID 74270
Author Hara Y, Watanabe K, Takaya A, Manome T, Yaguchi T, Ishibashi M.
Title Two Bioactive Compounds, Uniformides A and B, Isolated from a Culture of Nocardia uniformis IFM0856T in the Presence of Animal Cells.
Journal Org Lett
Abstract Two new peptides named uniformides A and B (1 and 2, respectively) were isolated from the cultured extracts of Nocardia uniformis IFM0856T in the presence of mouse macrophage-like cell line J774.1, in modified Czapek-Dox medium. These compounds were not produced in a culture containing only N. uniformis but in one that also included J774.1. Compounds 1 and 2 showed high cytotoxicity against J774.1 and suppressed the production of nitric oxide, IL-6, and IL-1β by inhibiting the NF-κB pathway.
Volume 24(27)
Pages 4998-5002
Published 2022-7-15
DOI 10.1021/acs.orglett.2c02092
PMID 35792521
MeSH Animals Cell Line Lipopolysaccharides / pharmacology Mice NF-kappa B / metabolism Nitric Oxide Nitric Oxide Synthase Type II / metabolism Nocardia* / metabolism
IF 6.091
Pathogenic eukaryotic microorganisms Nocardia uniformis IFM0856