| RRC ID |
74270
|
| 著者 |
Hara Y, Watanabe K, Takaya A, Manome T, Yaguchi T, Ishibashi M.
|
| タイトル |
Two Bioactive Compounds, Uniformides A and B, Isolated from a Culture of Nocardia uniformis IFM0856T in the Presence of Animal Cells.
|
| ジャーナル |
Org Lett
|
| Abstract |
Two new peptides named uniformides A and B (1 and 2, respectively) were isolated from the cultured extracts of Nocardia uniformis IFM0856T in the presence of mouse macrophage-like cell line J774.1, in modified Czapek-Dox medium. These compounds were not produced in a culture containing only N. uniformis but in one that also included J774.1. Compounds 1 and 2 showed high cytotoxicity against J774.1 and suppressed the production of nitric oxide, IL-6, and IL-1β by inhibiting the NF-κB pathway.
|
| 巻・号 |
24(27)
|
| ページ |
4998-5002
|
| 公開日 |
2022-7-15
|
| DOI |
10.1021/acs.orglett.2c02092
|
| PMID |
35792521
|
| MeSH |
Animals
Cell Line
Lipopolysaccharides / pharmacology
Mice
NF-kappa B / metabolism
Nitric Oxide
Nitric Oxide Synthase Type II / metabolism
Nocardia* / metabolism
|
| IF |
6.091
|
| リソース情報 |
| 病原真核微生物 |
Nocardia uniformis IFM0856 |
