論文 - 詳細
| RRC ID | 74384 |
|---|---|
| 著者 | Yamawaki Y, So H, Oue K, Asano S, Furusho H, Miyauchi M, Tanimoto K, Kanematsu T. |
| タイトル | Imipramine prevents Porphyromonas gingivalis lipopolysaccharide-induced microglial neurotoxicity. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Porphyromonas gingivalis (P. gingivalis) is a Gram-negative anaerobe involved in the pathogenesis of chronic periodontitis, including local inflammation of the oral cavity. However, periodontal disease has recently been identified as a significant factor in the pathogenesis of neural diseases, including Alzheimer's disease. A virulence factor, P. gingivalis-lipopolysaccharide (LPS-PG), is involved in pro-inflammatory responses, not only in peripheral tissues but also in the brain. In this study, we examined whether P. gingivalis-induced brain inflammation could be ameliorated by pharmacotherapy, using in vivo and in vitro studies. In an animal experiment, peripheral administration of LPS-PG induced inflammation in the hippocampus via microglial activation, which was inhibited by pre-treatment with the antidepressant imipramine. Similarly, LPS-PG-induced inflammation in MG-6 cells, a mouse microglial cell line, was inhibited by pre-treatment with imipramine, which caused imipramine-induced inhibition of NF-κB signaling. Culture media obtained from LPS-PG-treated MG-6 cells induced neuronal cell death in Neuro-2A cells, a mouse neuroblastoma cell line, which was prevented by pre-treatment of MG-6 cells with imipramine. These results indicate that imipramine inhibits LPS-PG-induced inflammatory responses in microglia and ameliorates periodontal disease-related neural damage. |
| 巻・号 | 634 |
| ページ | 92-99 |
| 公開日 | 2022-12-17 |
| DOI | 10.1016/j.bbrc.2022.09.109 |
| PII | S0006-291X(22)01371-7 |
| PMID | 36240654 |
| MeSH | Animals Imipramine / pharmacology Inflammation / drug therapy Inflammation / metabolism Inflammation / prevention & control Lipopolysaccharides / pharmacology Mice Microglia / metabolism NF-kappa B / metabolism Periodontal Diseases* Porphyromonas gingivalis* / metabolism |
| IF | 2.985 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MG-63(RCB1890) |