論文 - 詳細
| RRC ID | 74392 |
|---|---|
| 著者 | Miura S, Oyanagi E, Watanabe C, Hamada H, Aoki T, Kremenik MJ, Yano H. |
| タイトル | Acetyl-L-carnitine attenuates Poly I:C-induced sickness behavior in mice. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
Fatigue is accompanied by a decrease in physical activity or malaise, and might be reduced by acetyl-L-carnitine (ALC) administration. The purpose of this study was to investigate the preventive effects of ALC on Poly I:C-induced sickness behavior in mice. For the experiment, male C3H/HeN mice were used and treated with ALC for 5 days before Poly I:C administration. ALC administration attenuated the decrease in wheel behavior activity of mice at 24 h after Poly I:C administration and ALC-treated mice quickly recovered from the sickness behavior. The gene expression of brain-derived neurotrophic factor (BDNF) in the cerebrum and hippocampus, which is associated with physical activity, was higher in the ALC-treated group. Translocator protein 18kDa (TSPO), which has cytoprotective effects, was up-regulated in the cerebrum and hippocampus, suggesting that ALC suppressed the decrease in activity induced by Poly I:C treatment through enhancement of cytoprotective effects in the brain. |
| 巻・号 | 86(10) |
| ページ | 1423-1430 |
| 公開日 | 2022-9-23 |
| DOI | 10.1093/bbb/zbac132 |
| PII | 6659189 |
| PMID | 35945649 |
| MeSH | Acetylcarnitine* / pharmacology Acetylcarnitine* / therapeutic use Animals Brain-Derived Neurotrophic Factor* / genetics Brain-Derived Neurotrophic Factor* / metabolism Illness Behavior Male Mice Mice, Inbred C3H Poly I-C / pharmacology |
| IF | 1.516 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |