| RRC ID |
74392
|
| 著者 |
Miura S, Oyanagi E, Watanabe C, Hamada H, Aoki T, Kremenik MJ, Yano H.
|
| タイトル |
Acetyl-L-carnitine attenuates Poly I:C-induced sickness behavior in mice.
|
| ジャーナル |
Biosci Biotechnol Biochem
|
| Abstract |
Fatigue is accompanied by a decrease in physical activity or malaise, and might be reduced by acetyl-L-carnitine (ALC) administration. The purpose of this study was to investigate the preventive effects of ALC on Poly I:C-induced sickness behavior in mice. For the experiment, male C3H/HeN mice were used and treated with ALC for 5 days before Poly I:C administration. ALC administration attenuated the decrease in wheel behavior activity of mice at 24 h after Poly I:C administration and ALC-treated mice quickly recovered from the sickness behavior. The gene expression of brain-derived neurotrophic factor (BDNF) in the cerebrum and hippocampus, which is associated with physical activity, was higher in the ALC-treated group. Translocator protein 18kDa (TSPO), which has cytoprotective effects, was up-regulated in the cerebrum and hippocampus, suggesting that ALC suppressed the decrease in activity induced by Poly I:C treatment through enhancement of cytoprotective effects in the brain.
|
| 巻・号 |
86(10)
|
| ページ |
1423-1430
|
| 公開日 |
2022-9-23
|
| DOI |
10.1093/bbb/zbac132
|
| PII |
6659189
|
| PMID |
35945649
|
| MeSH |
Acetylcarnitine* / pharmacology
Acetylcarnitine* / therapeutic use
Animals
Brain-Derived Neurotrophic Factor* / genetics
Brain-Derived Neurotrophic Factor* / metabolism
Illness Behavior
Male
Mice
Mice, Inbred C3H
Poly I-C / pharmacology
|
| IF |
1.516
|
| リソース情報 |
| ヒト・動物細胞 |
RAW 264(RCB0535) |
