| RRC ID |
74421
|
| 著者 |
Wang D, Nagata M, Matsumoto M, Amen Y, Wang D, Shimizu K.
|
| タイトル |
Potential of Hibiscus sabdariffa L. and Hibiscus Acid to Reverse Skin Aging.
|
| ジャーナル |
Molecules
|
| Abstract |
Hibiscus sabdariffa L. (HS) has a long history of edible and medicinal uses. In this study, the biological activities of the extracts, chromatographic fractions, and hibiscus acid obtained from HS were evaluated for their potential bioactivities. Their ability to promote extracellular matrix synthesis in skin fibroblasts was evaluated by enzyme-linked immunosorbent assays. Their anti-inflammatory activity was evaluated in a nitric oxide (NO)-Griess inflammatory experiment. Furthermore, hibiscus acid was found to have a strong anti-oxidative stress effect through the establishment of an oxidative stress model induced by hydrogen peroxide. Several assays indicated that hibiscus acid treatment can effectively reduce extracellular adenosine triphosphate (ATP) secretion and carbonyl protein production, as well as maintain a high level of reduced/oxidized glutathione (GSH/GSSG) in skin cells, thus providing a possible mechanism by which hibiscus acid can counter antioxidative stress. The present study is the first to explore the reversing skin aging potential and the contributory component of HS.
|
| 巻・号 |
27(18)
|
| 公開日 |
2022-9-17
|
| DOI |
10.3390/molecules27186076
|
| PII |
molecules27186076
|
| PMID |
36144809
|
| PMC |
PMC9504376
|
| MeSH |
Adenosine Triphosphate
Anti-Inflammatory Agents
Citrates
Glutathione Disulfide
Hibiscus* / chemistry
Hydrogen Peroxide
Nitric Oxide
Plant Extracts / chemistry
Plant Extracts / pharmacology
Skin Aging*
|
| IF |
3.267
|
| リソース情報 |
| ヒト・動物細胞 |
RAW 264(RCB0535) |
