Reference - Detail
| RRC ID | 74424 |
|---|---|
| Author | Nakashima KI, Higuchi Y, Tomida J, Kawamura Y, Inoue M. |
| Title | Two new ɑ-pyrone derivatives from the endophytic Diaporthe sp. ECN371. |
| Journal | J Nat Med |
| Abstract |
Diaportholides A (1) and B (2), two polyketides with ɑ-pyrone moieties, were isolated from the cultures of an endophytic Diaporthe sp. ECN371 isolated from Orixa japonica, together with four known polyketides, phomopsolide B (3), phomopsolidones A (4) and B (5), and 5-[(1R)-1-hydroxyethyl]-γ-oxo-2-furanbutanoic acid (6). The structures of 1 and 2 were determined by extensive analysis of NMR and MS spectroscopic data. Furthermore, the structure of 2 was confirmed by analyzing the single-crystal X-ray diffraction data. The luciferase reporter gene assay revealed that among all isolated compounds (1-6), 3, a known ɑ-pyrone derivative, exhibited agonistic activity against the peroxisome proliferator-activated receptor ɑ, which is an important regulator of lipid metabolism in humans. |
| Volume | 76(2) |
| Pages | 462-467 |
| Published | 2022-3-1 |
| DOI | 10.1007/s11418-021-01586-y |
| PII | 10.1007/s11418-021-01586-y |
| PMID | 34981405 |
| MeSH | Crystallography, X-Ray Humans Molecular Structure Polyketides* / pharmacology Pyrones* / pharmacology |
| IF | 2.055 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | Hep G2 |