論文 - 詳細
| RRC ID | 74501 |
|---|---|
| 著者 | Cabrera AJH, Gumbiner BM, Kwon YV. |
| タイトル | Remodeling of E-cadherin subcellular localization during cell dissemination. |
| ジャーナル | Mol Biol Cell |
| Abstract |
Given the role of E-cadherin (E-cad) in holding epithelial cells together, an inverse relationship between E-cad levels and cell invasion during the epithelial-mesenchymal transition and cancer metastasis has been well recognized. Here we report that E-cad is necessary for the invasiveness of RasV12-transformed intestinal epithelial cells in Drosophila. E-cad/β-catenin disassembles at adherens junctions and assembles at invasive protrusions--the actin- and cortactin-rich invadopodium-like protrusions associated with the breach of the extracellular matrix (ECM)--during dissemination of RasV12-transformed intestinal epithelial cells. Loss of E-cad impairs the elongation of invasive protrusions and attenuates the ability of RasV12-transformed cells to compromise the ECM. Notably, E-cad and cortactin affect each other's localization to invasive protrusions. Given the essential roles of cortactin in cell invasion, our observations indicate that E-cad plays a role in the invasiveness of RasV12-transformed intestinal epithelial cells by controlling cortactin localization to invasive protrusions. Thus our study demonstrates that E-cad is a component of invasive protrusions and provides molecular insights into the unconventional role of E-cad in cell dissemination in vivo. |
| 巻・号 | 34(5) |
| ページ | ar46 |
| 公開日 | 2023-5-1 |
| DOI | 10.1091/mbc.E23-03-0087 |
| PMID | 36989029 |
| MeSH | Actins / metabolism Adherens Junctions / metabolism Animals Cadherins* / metabolism Cortactin* / metabolism Drosophila / metabolism Epithelial Cells / metabolism |
| IF | 3.791 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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| ショウジョウバエ | |