論文 - 詳細
| RRC ID | 74569 |
|---|---|
| 著者 | Yu X, Wang X, Yamazaki A, Li X. |
| タイトル | Tumor microenvironment-regulated nanoplatforms for the inhibition of tumor growth and metastasis in chemo-immunotherapy. |
| ジャーナル | J Mater Chem B |
| Abstract |
Chemotherapy is one of the major clinical anticancer therapies. However, its efficiency is limited by many factors, including the complex tumor microenvironment (TME). Herein, manganese-doped mesoporous silica nanoparticles (MM NPs) were constructed and applied to regulate the TME and enhance the efficiency of the combination of chemotherapy and immunotherapy (chemo-immunotherapy). Notably, the combination of MM NPs, doxorubicin hydrochloride, and immune checkpoint inhibitors enhanced the synergistic efficiency of chemo-immunotherapy in a bilateral animal model, which simultaneously inhibited the growth of primary tumors and distant untreated tumors. Moreover, Mn-doping endowed MSNs with six new regulatory functions for the TME by inducing glutathione depletion, ROS generation, oxygenation, cell-killing effect, immune activation, and degradation promotion. These results demonstrated that MM NPs with TME regulatory functions can potentially improve the efficiency of chemo-immunotherapy. |
| 巻・号 | 10(19) |
| ページ | 3637-3647 |
| 公開日 | 2022-5-18 |
| DOI | 10.1039/d2tb00337f |
| PMID | 35439801 |
| MeSH | Animals Doxorubicin / pharmacology Doxorubicin / therapeutic use Immunologic Factors / pharmacology Immunotherapy / methods Nanoparticles* / therapeutic use Neoplasms* / drug therapy Tumor Microenvironment |
| IF | 5.344 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | THP-1 |