Reference - Detail
| RRC ID | 74618 |
|---|---|
| Author | Niu J, Qi J, Wang P, Liu C, Gao JM. |
| Title | The chemical structures and biological activities of indole diterpenoids. |
| Journal | Nat Prod Bioprospect |
| Abstract |
Indole diterpenoids (IDTs) are an essential class of structurally diverse fungal secondary metabolites, that generally appear to be restricted to a limited number of fungi, such as Penicillium, Aspergillus, Claviceps, and Epichloe species, etc. These compounds share a typical core structure consisting of a cyclic diterpene skeleton of geranylgeranyl diphosphate (GGPP) and an indole ring moiety derived from indole-3-glycerol phosphate (IGP). 3-geranylgeranylindole (3-GGI) is the common precursor of all IDTs. On this basis, it is modified by cyclization, oxidation, and prenylation to generate a large class of compounds with complex structures. These compounds exhibit antibacterial, anti-insect, and ion channel inhibitory activities. We summarized 204 compounds of IDTs discovered from various fungi over the past 50 years, these compounds were reclassified, and their biological activities were summarized. This review will help to understand the structural diversity of IDTs and provide help for their physiological activities. |
| Volume | 13(1) |
| Pages | 3 |
| Published | 2023-1-3 |
| DOI | 10.1007/s13659-022-00368-7 |
| PII | 10.1007/s13659-022-00368-7 |
| PMID | 36595079 |
| PMC | PMC9810782 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Wikipedia |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 6.0 |
| Resource | |
| Pathogenic eukaryotic microorganisms | Aspergillus fumigatus IFM 41362, Aspergillus niger IFM 41398 |