Reference - Detail
| RRC ID | 74620 |
|---|---|
| Author | Morishita Y, Tsukada K, Murakami K, Irie K, Asai T. |
| Title | Synthetic Biology-Based Discovery of Diterpenoid Pyrones from the Genome of Eupenicillium shearii. |
| Journal | J Nat Prod |
| Abstract |
Diterpenoid pyrones are a type of mainly fungal meroterpenoid metabolite consisting of a diterpene connected to a pyrone, some of which show potent bioactivity. Through genome mining and heterologous expression, nine new diterpenoid pyrones, shearones A-I (1-9), were discovered from the fungus Eupenicillium shearii IFM 42152, and their biosynthetic enzyme activities were revealed. Some of these heterologously biosynthesized diterpenoid pyrones exhibited moderate antiaggregative ability against amyloid β42 in vitro. |
| Volume | 85(2) |
| Pages | 384-390 |
| Published | 2022-2-25 |
| DOI | 10.1021/acs.jnatprod.1c00973 |
| PMID | 35057611 |
| MeSH | Diterpenes* / metabolism Diterpenes* / pharmacology Penicillium Pyrones* / pharmacology Synthetic Biology |
| IF | 3.782 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Pathogenic eukaryotic microorganisms | Eupenicillium shearii IFM 42152 |