論文 - 詳細
| RRC ID | 74678 |
|---|---|
| 著者 | Lee EH, Zinshteyn D, Miglo F, Wang MQ, Reinach J, Chau CM, Grosstephan JM, Correa I, Costa K, Vargas A, Johnson A, Longo SM, Alexander JI, O'Reilly AM. |
| タイトル | Sequential events during the quiescence to proliferation transition establish patterns of follicle cell differentiation in the Drosophila ovary. |
| ジャーナル | Biol Open |
| Abstract |
Stem cells cycle between periods of quiescence and proliferation to promote tissue health. In Drosophila ovaries, quiescence to proliferation transitions of follicle stem cells (FSCs) are exquisitely feeding-dependent. Here, we demonstrate feeding-dependent induction of follicle cell differentiation markers, eyes absent (Eya) and castor (Cas) in FSCs, a patterning process that does not depend on proliferation induction. Instead, FSCs extend micron-scale cytoplasmic projections that dictate Eya-Cas patterning. We identify still life and sickie as necessary and sufficient for FSC projection growth and Eya-Cas induction. Our results suggest that sequential, interdependent events establish long-term differentiation patterns in follicle cell precursors, independently of FSC proliferation induction. |
| 巻・号 | 12(1) |
| 公開日 | 2023-1-1 |
| DOI | 10.1242/bio.059625 |
| PII | 285987 |
| PMID | 36524613 |
| PMC | PMC9867896 |
| MeSH | Animals Cell Differentiation Cell Division Drosophila / metabolism Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster / metabolism Female Ovary* / metabolism |
| IF | 2.029 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#118157 DGRC#103673 |