論文 - 詳細
| RRC ID | 74698 |
|---|---|
| 著者 | Ayukawa T, Akiyama M, Hozumi Y, Ishimoto K, Sasaki J, Senoo H, Sasaki T, Yamazaki M. |
| タイトル | Tissue flow regulates planar cell polarity independently of the Frizzled core pathway. |
| ジャーナル | Cell Rep |
| Abstract |
Planar cell polarity (PCP) regulates the orientation of external structures. A core group of proteins that includes Frizzled forms the heart of the PCP regulatory system. Other PCP mechanisms that are independent of the core group likely exist, but their underlying mechanisms are elusive. Here, we show that tissue flow is a mechanism governing core group-independent PCP on the Drosophila notum. Loss of core group function only slightly affects bristle orientation in the adult central notum. This near-normal PCP results from tissue flow-mediated rescue of random bristle orientation during the pupal stage. Manipulation studies suggest that tissue flow can orient bristles in the opposite direction to the flow. This process is independent of the core group and implies that the apical extracellular matrix functions like a "comb" to align bristles. Our results reveal the significance of cooperation between tissue dynamics and extracellular substances in PCP establishment. |
| 巻・号 | 40(12) |
| ページ | 111388 |
| 公開日 | 2022-9-20 |
| DOI | 10.1016/j.celrep.2022.111388 |
| PII | S2211-1247(22)01225-6 |
| PMID | 36130497 |
| MeSH | Animals Cell Polarity* / physiology Drosophila / metabolism Drosophila Proteins* / metabolism Frizzled Receptors / metabolism Pupa / metabolism |
| IF | 8.109 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#115238 |