Reference - Detail
| RRC ID | 74716 |
|---|---|
| Author | Orr BO, Fetter RD, Davis GW. |
| Title | Activation and expansion of presynaptic signaling foci drives presynaptic homeostatic plasticity. |
| Journal | Neuron |
| Abstract |
Presynaptic homeostatic plasticity (PHP) adaptively regulates synaptic transmission in health and disease. Despite identification of numerous genes that are essential for PHP, we lack a dynamic framework to explain how PHP is initiated, potentiated, and limited to achieve precise control of vesicle fusion. Here, utilizing both mice and Drosophila, we demonstrate that PHP progresses through the assembly and physical expansion of presynaptic signaling foci where activated integrins biochemically converge with trans-synaptic Semaphorin2b/PlexinB signaling. Each component of the identified signaling complexes, including alpha/beta-integrin, Semaphorin2b, PlexinB, talin, and focal adhesion kinase (FAK), and their biochemical interactions, are essential for PHP. Complex integrity requires the Sema2b ligand and complex expansion includes a ∼2.5-fold expansion of active-zone associated puncta composed of the actin-binding protein talin. Finally, complex pre-expansion is sufficient to accelerate the rate and extent of PHP. A working model is proposed incorporating signal convergence with dynamic molecular assemblies that instruct PHP. |
| Volume | 110(22) |
| Pages | 3743-3759.e6 |
| Published | 2022-11-16 |
| DOI | 10.1016/j.neuron.2022.08.016 |
| PII | S0896-6273(22)00748-6 |
| PMID | 36087584 |
| PMC | PMC9671843 |
| MeSH | Animals Drosophila / metabolism Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster / physiology Mice Neuronal Plasticity / physiology Presynaptic Terminals / metabolism Talin / metabolism |
| IF | 14.415 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 10 |
| Altmetric score changes over past 6months | 0.2 |
| Resource | |
| Drosophila | DGRC#115524 |