論文 - 詳細
| RRC ID | 74734 |
|---|---|
| 著者 | Moreno MR, Boswell K, Casbolt HL, Bulgakova NA. |
| タイトル | Multifaceted control of E-cadherin dynamics by Adaptor Protein Complex 1 during epithelial morphogenesis. |
| ジャーナル | Mol Biol Cell |
| Abstract |
Intracellular trafficking regulates the distribution of transmembrane proteins including the key determinants of epithelial polarity and adhesion. The Adaptor Protein 1 (AP-1) complex is the key regulator of vesicle sorting, which binds many specific cargoes. We examined roles of the AP-1 complex in epithelial morphogenesis, using the Drosophila wing as a paradigm. We found that AP-1 knockdown leads to ectopic tissue folding, which is consistent with the observed defects in integrin targeting to the basal cell-extracellular matrix adhesion sites. This occurs concurrently with an integrin-independent induction of cell death, which counteracts elevated proliferation and prevents hyperplasia. We discovered a distinct pool of AP-1 that localizes at the subapical adherens junctions. Upon AP-1 knockdown, E-cadherin is hyperinternalized from these junctions and becomes enriched at the Golgi and recycling endosomes. We then provide evidence that E-cadherin hyperinternalization acts upstream of cell death in a potential tumor-suppressive mechanism. Simultaneously, cells compensate for elevated internalization of E-cadherin by increasing its expression to maintain cell-cell adhesion. |
| 巻・号 | 33(9) |
| ページ | ar80 |
| 公開日 | 2022-8-1 |
| DOI | 10.1091/mbc.E21-12-0598 |
| PMID | 35609212 |
| PMC | PMC9582639 |
| MeSH | Adaptor Protein Complex 1* / metabolism Adherens Junctions / metabolism Animals Cadherins / metabolism Cell Polarity Drosophila / metabolism Epithelial Cells / metabolism Integrins / metabolism Morphogenesis / physiology Protein Transport / physiology Transcription Factor AP-1* / metabolism |
| IF | 3.791 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#109007 |