論文 - 詳細
| RRC ID | 74779 |
|---|---|
| 著者 | Iwasaki M, Kawakami K, Wada H. |
| タイトル | Remodeling of the hyomandibular skeleton and facial nerve positioning during embryonic and postembryonic development of teleost fish. |
| ジャーナル | Dev Biol |
| Abstract |
The vertebrate skeleton changes its shape during development through the activities of chondrocytes, osteoblasts and osteoclasts. Although much is known about the mechanisms for differentiation in these cells, it is less understood how they behave in a region-specific manner to acquire unique bone shapes. To address this question, we investigated the development of the hyomandibular (Hm) system in zebrafish. The Hm originates as cartilage carrying a single foramen (the Hm foramen), through which the facial (VII) nerve passes. We reveal that Schwann cells, which myelinate the VII nerve, regulate rearrangement of the chondrocytes to enlarge the Hm foramen. The Hm cartilage then becomes ossified in the perichondrium, where the marrow chondrocytes are replaced by adipocytes. Then, the bone matrix along the VII nerve is resorbed by osteoclasts, generating a gateway to the bone marrow. Subsequent movement of the VII nerve into the marrow, followed by deposition of new bone matrix, isolates the nerve from the jaw muscle insertion. Genetic ablation of osteoblasts and osteoclasts reveals specific roles of these cells during remodeling processes. Interestingly, the VII nerve relocation does not occur in medaka; instead, bone deposition distinct from those in zebrafish separates the VII nerve from the muscle insertion. Our results define novel mechanisms for skeletal remodeling, by which the bone shapes in a region- and species-specific manner. |
| 巻・号 | 489 |
| ページ | 134-145 |
| 公開日 | 2022-9-1 |
| DOI | 10.1016/j.ydbio.2022.06.009 |
| PII | S0012-1606(22)00126-9 |
| PMID | 35750208 |
| MeSH | Animals Bone Remodeling / physiology Bone and Bones Facial Nerve* Osteoblasts Osteoclasts Zebrafish* / genetics |
| IF | 2.896 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | gSAGFF202A Tg(mmp9:egfp)tyt206 HGn39D hspGFFDMC13F UAS:EGFP UAS:RFP |