論文 - 詳細
| RRC ID | 74785 |
|---|---|
| 著者 | Goldblatt D, Huang S, Greaney MR, Hamling KR, Voleti V, Perez-Campos C, Patel KB, Li W, Hillman EMC, Bagnall MW, Schoppik D. |
| タイトル | Neuronal birthdate reveals topography in a vestibular brainstem circuit for gaze stabilization. |
| ジャーナル | Curr Biol |
| Abstract |
Across the nervous system, neurons with similar attributes are topographically organized. This topography reflects developmental pressures. Oddly, vestibular (balance) nuclei are thought to be disorganized. By measuring activity in birthdated neurons, we revealed a functional map within the central vestibular projection nucleus that stabilizes gaze in the larval zebrafish. We first discovered that both somatic position and stimulus selectivity follow projection neuron birthdate. Next, with electron microscopy and loss-of-function assays, we found that patterns of peripheral innervation to projection neurons were similarly organized by birthdate. Finally, birthdate revealed spatial patterns of axonal arborization and synapse formation to projection neuron outputs. Collectively, we find that development reveals previously hidden organization to the input, processing, and output layers of a highly conserved vertebrate sensorimotor circuit. The spatial and temporal attributes we uncover constrain the developmental mechanisms that may specify the fate, function, and organization of vestibulo-ocular reflex neurons. More broadly, our data suggest that, like invertebrates, temporal mechanisms may assemble vertebrate sensorimotor architecture. |
| 巻・号 | 33(7) |
| ページ | 1265-1281.e7 |
| 公開日 | 2023-4-10 |
| DOI | 10.1016/j.cub.2023.02.048 |
| PII | S0960-9822(23)00188-4 |
| PMID | 36924768 |
| PMC | PMC10089979 |
| MeSH | Animals Brain Stem Neurons* / physiology Reflex, Vestibulo-Ocular / physiology Vestibular Nuclei / physiology Zebrafish* / physiology |
| IF | 9.601 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(CM-isl1:GFP)rw0 |