| RRC ID |
74817
|
| 著者 |
Yang E, Zwart MF, James B, Rubinov M, Wei Z, Narayan S, Vladimirov N, Mensh BD, Fitzgerald JE, Ahrens MB.
|
| タイトル |
A brainstem integrator for self-location memory and positional homeostasis in zebrafish.
|
| ジャーナル |
Cell
|
| Abstract |
To track and control self-location, animals integrate their movements through space. Representations of self-location are observed in the mammalian hippocampal formation, but it is unknown if positional representations exist in more ancient brain regions, how they arise from integrated self-motion, and by what pathways they control locomotion. Here, in a head-fixed, fictive-swimming, virtual-reality preparation, we exposed larval zebrafish to a variety of involuntary displacements. They tracked these displacements and, many seconds later, moved toward their earlier location through corrective swimming ("positional homeostasis"). Whole-brain functional imaging revealed a network in the medulla that stores a memory of location and induces an error signal in the inferior olive to drive future corrective swimming. Optogenetically manipulating medullary integrator cells evoked displacement-memory behavior. Ablating them, or downstream olivary neurons, abolished displacement corrections. These results reveal a multiregional hindbrain circuit in vertebrates that integrates self-motion and stores self-location to control locomotor behavior.
|
| 巻・号 |
185(26)
|
| ページ |
5011-5027.e20
|
| 公開日 |
2022-12-22
|
| DOI |
10.1016/j.cell.2022.11.022
|
| PII |
S0092-8674(22)01466-0
|
| PMID |
36563666
|
| MeSH |
Animals
Brain / physiology
Homeostasis
Mammals
Neurons* / physiology
Rhombencephalon / physiology
Swimming / physiology
Zebrafish* / physiology
|
| IF |
38.637
|
| リソース情報 |
| ゼブラフィッシュ |
Tg(vglut2a:loxP-DsRed-loxP-GFP)
Tg(glyt2:|R|-GFP) |
