論文 - 詳細
| RRC ID | 74820 |
|---|---|
| 著者 | Nam D, Park A, Dubon MJ, Yu J, Kim W, Son Y, Park KS. |
| タイトル | Coordinated Regulation of Mesenchymal Stem Cell Migration by Various Chemotactic Stimuli. |
| ジャーナル | Int J Mol Sci |
| Abstract |
Endogenous bone marrow-derived mesenchymal stem cells are mobilized to peripheral blood and injured tissues in response to changes in the expression of various growth factors and cytokines in the injured tissues, including substance P (SP), transforming growth factor-beta (TGF-β), and stromal cell-derived factor-1 (SDF-1). SP, TGF-β, and SDF-1 are all known to induce the migration of bone marrow-derived mesenchymal stem cells (BM-MSCs). However, it is not yet clear how these stimuli influence or interact with each other during BM-MSC mobilization. This study used mouse bone marrow-derived mesenchymal stem cell-like ST2 cells and human BM-MSCs to evaluate whether SP, TGF-β, and SDF-1 mutually regulate their respective effects on the mobilization of BM-MSCs. SP pretreatment of ST2 and BM-MSCs impaired their response to TGF-β while the introduction of SP receptor antagonist restored the mobilization of ST2 and BM-MSCs in response to TGF-β. TGF-β pretreatment did not affect the migration of ST2 and BM-MSCs in response to SP, but downregulated their migration in response to SDF-1. SP pretreatment modulated the activation of TGF-β noncanonical pathways in ST2 cells and BM-MSCs, but not canonical pathways. These results suggest that the migration of mesenchymal stem cells is regulated by complex functional interactions between SP, TGF-β, and SDF-1. Thus, understanding the complex functional interactions of these chemotactic stimuli would contribute to ensuring the development of safe and effective combination treatments for the mobilization of BM-MSCs. |
| 巻・号 | 21(22) |
| 公開日 | 2020-11-13 |
| DOI | 10.3390/ijms21228561 |
| PII | ijms21228561 |
| PMID | 33202862 |
| PMC | PMC7696304 |
| MeSH | Animals Bone Marrow Cells / cytology Bone Marrow Cells / immunology* Cell Line Chemokine CXCL12 / immunology Chemotaxis / immunology* Humans Mesenchymal Stem Cells / cytology Mesenchymal Stem Cells / immunology* Mice Signal Transduction / immunology* Transforming Growth Factor beta / immunology |
| IF | 4.556 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | ST2(RCB0224) |