論文 - 詳細
| RRC ID | 74897 |
|---|---|
| 著者 | Miyamoto Y, Iwasaki A, Fujimura H, Kudo C, Kurisawa N, Ohno O, Suenaga K. |
| タイトル | Total Synthesis of Caldorazole, a Potent Mitochondrial Respiratory Chain Inhibitor without Chiral Centers. |
| ジャーナル | J Org Chem |
| Abstract |
Caldorazole (1) is a novel polyketide that was isolated from a marine cyanobacterium in 2022. It is a unique natural product that exhibits potent inhibitory activity against mitochondrial respiratory chain complex I despite having no chiral centers. To establish a method for obtaining caldorazole without relying on biological resources and for constructing a useful synthetic route for studies of its structure-activity relationship, we achieved the first total synthesis of caldorazole using a convergent synthetic route. |
| 巻・号 | 88(5) |
| ページ | 3208-3216 |
| 公開日 | 2023-3-3 |
| DOI | 10.1021/acs.joc.2c03007 |
| PMID | 36800251 |
| MeSH | Cyanobacteria* Electron Transport Polyketides* / pharmacology Stereoisomerism Structure-Activity Relationship |
| IF | 4.335 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HeLa |