| RRC ID |
74897
|
| 著者 |
Miyamoto Y, Iwasaki A, Fujimura H, Kudo C, Kurisawa N, Ohno O, Suenaga K.
|
| タイトル |
Total Synthesis of Caldorazole, a Potent Mitochondrial Respiratory Chain Inhibitor without Chiral Centers.
|
| ジャーナル |
J Org Chem
|
| Abstract |
Caldorazole (1) is a novel polyketide that was isolated from a marine cyanobacterium in 2022. It is a unique natural product that exhibits potent inhibitory activity against mitochondrial respiratory chain complex I despite having no chiral centers. To establish a method for obtaining caldorazole without relying on biological resources and for constructing a useful synthetic route for studies of its structure-activity relationship, we achieved the first total synthesis of caldorazole using a convergent synthetic route.
|
| 巻・号 |
88(5)
|
| ページ |
3208-3216
|
| 公開日 |
2023-3-3
|
| DOI |
10.1021/acs.joc.2c03007
|
| PMID |
36800251
|
| MeSH |
Cyanobacteria*
Electron Transport
Polyketides* / pharmacology
Stereoisomerism
Structure-Activity Relationship
|
| IF |
4.335
|
| リソース情報 |
| ヒト・動物細胞 |
HeLa |
