論文 - 詳細
| RRC ID | 74898 |
|---|---|
| 著者 | Shoji A, Arai Y, Asakawa R, Saito T, Kuramochi K, Yajima A. |
| タイトル | Synthesis and structure-activity relationship of violaceoid D, a cytotoxic alkylated phenol isolated from Aspergillus violaceofuscus Gasperini. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
The enantioselective synthesis of violaceoid D, a cytotoxic phenolic compound isolated from the culture broth of Aspergillus violaceofuscus Gasperini, was achieved. The total synthesis involves stereoselective construction of the stereogenic center of violaceoid D via Sharpless asymmetric dihydroxylation, followed by Smiles rearrangement. The absolute configuration of natural violaceoid D was determined to be R from the specific rotation value. Synthesized violaceoid D and its analogs were evaluated for cytotoxicity against two human cancer cell lines, Jurkat and HCT116. Because the enantiomer of violaceoid D showed no cytotoxicity, it is plausible that violaceoid D binds selectively to specific target molecules, such as proteins in the cancer cells. |
| 巻・号 | 87(4) |
| ページ | 363-370 |
| 公開日 | 2023-3-21 |
| DOI | 10.1093/bbb/zbac212 |
| PII | 6967133 |
| PMID | 36592963 |
| MeSH | Antineoplastic Agents* / pharmacology Humans Molecular Structure Phenol* Phenols / pharmacology Stereoisomerism Structure-Activity Relationship |
| IF | 1.516 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HCT116(RCB2979) |