論文 - 詳細
| RRC ID | 74998 |
|---|---|
| 著者 | Dang P, Barnes DT, Cheng RP, Xu A, Moon YJ, Kodukula SS, Raper JA. |
| タイトル | Netrins and Netrin Receptors are Essential for Normal Targeting of Sensory Axons in the Zebrafish Olfactory Bulb. |
| ジャーナル | Neuroscience |
| Abstract |
Olfactory sensory neurons that express related odorant receptors specifically target large identifiable neuropils called protoglomeruli when they first reach the olfactory bulb in the zebrafish. This crude odorant receptor-related mapping is further refined as odorant receptor-specific glomeruli segregate from protoglomeruli later in development. Netrins are a prominent class of axon guidance molecules whose contribution to olfactory circuit formation is poorly studied. Morpholino knock down experiments have suggested that Netrin/Dcc signaling is involved in normal protoglomerular targeting. Here we extend these findings with more detailed characterization and modeling of netrin expression, and by examining protoglomerular targeting in mutant lines fornetrin1a (ntn1a), netrin1b (ntn1b), and their receptorsunc5b,dcc, andneo1a. We confirm thatntn1a,ntn1b, anddccare required for normal protoglomerular guidance of a subset of olfactory sensory neurons that are labeled with the Tg(or111-7:IRES:Gal4) transgene. We also observe errors in the targeting of these axons inunc5bmutants, but not inneo1a mutants. Our findings are consistent with ntn1a andntn1bacting primarily as attractants for olfactory sensory neurons targeting the central zone protoglomerulus. |
| 巻・号 | 508 |
| ページ | 19-29 |
| 公開日 | 2023-1-1 |
| DOI | 10.1016/j.neuroscience.2022.08.004 |
| PII | S0306-4522(22)00407-9 |
| PMID | 35940453 |
| PMC | PMC9839495 |
| MeSH | Animals Axons / metabolism Netrin Receptors / metabolism Netrin-1 / metabolism Netrins / metabolism Olfactory Bulb / metabolism Olfactory Receptor Neurons* / physiology Receptors, Odorant* / metabolism Zebrafish / metabolism |
| IF | 3.056 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 12 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(-2.0omp:lyn-mRFP)rw035 Tg(-4.5trpc2:gap-Venus)rw037 |