| RRC ID |
75023
|
| Author |
Serizawa K, Miyake S, Katsura Y, Yorozu K, Kurasawa M, Tomizawa-Shinohara H, Yasuno H, Matsumoto Y.
|
| Title |
Intradermal AQP4 peptide immunization induces clinical features of neuromyelitis optica spectrum disorder in mice.
|
| Journal |
J Neuroimmunol
|
| Abstract |
We challenged to create a mouse model of neuromyelitis optica spectrum disorder (NMOSD) induced by AQP4 peptide immunization. Intradermal immunization with AQP4 p201-220 peptide induced paralysis in C57BL/6J mice, but not in AQP4 KO mice. AQP4 peptide-immunized mice showed pathological features similar to NMOSD. Administration of anti-IL-6 receptor antibody (MR16-1) inhibited the induction of clinical signs and prevented the loss of GFAP/AQP4 and deposition of complement factors in AQP4 peptide-immunized mice. This novel experimental model may contribute to further understanding the pathogenesis of NMOSD, elucidating the mechanism of action of therapeutic agents, and developing new therapeutic approaches.
|
| Volume |
380
|
| Pages |
578109
|
| Published |
2023-7-15
|
| DOI |
10.1016/j.jneuroim.2023.578109
|
| PII |
S0165-5728(23)00095-4
|
| PMID |
37210799
|
| MeSH |
Animals
Aquaporin 4
Autoantibodies
Immunization
Mice
Mice, Inbred C57BL
Neuromyelitis Optica*
Peptides
|
| IF |
3.125
|
| Resource |
| Mice |
RBRC10053 |
