RRC ID 75023
Author Serizawa K, Miyake S, Katsura Y, Yorozu K, Kurasawa M, Tomizawa-Shinohara H, Yasuno H, Matsumoto Y.
Title Intradermal AQP4 peptide immunization induces clinical features of neuromyelitis optica spectrum disorder in mice.
Journal J Neuroimmunol
Abstract We challenged to create a mouse model of neuromyelitis optica spectrum disorder (NMOSD) induced by AQP4 peptide immunization. Intradermal immunization with AQP4 p201-220 peptide induced paralysis in C57BL/6J mice, but not in AQP4 KO mice. AQP4 peptide-immunized mice showed pathological features similar to NMOSD. Administration of anti-IL-6 receptor antibody (MR16-1) inhibited the induction of clinical signs and prevented the loss of GFAP/AQP4 and deposition of complement factors in AQP4 peptide-immunized mice. This novel experimental model may contribute to further understanding the pathogenesis of NMOSD, elucidating the mechanism of action of therapeutic agents, and developing new therapeutic approaches.
Volume 380
Pages 578109
Published 2023-7-15
DOI 10.1016/j.jneuroim.2023.578109
PII S0165-5728(23)00095-4
PMID 37210799
MeSH Animals Aquaporin 4 Autoantibodies Immunization Mice Mice, Inbred C57BL Neuromyelitis Optica* Peptides
IF 3.125
Mice RBRC10053