論文 - 詳細
| RRC ID | 75023 |
|---|---|
| 著者 | Serizawa K, Miyake S, Katsura Y, Yorozu K, Kurasawa M, Tomizawa-Shinohara H, Yasuno H, Matsumoto Y. |
| タイトル | Intradermal AQP4 peptide immunization induces clinical features of neuromyelitis optica spectrum disorder in mice. |
| ジャーナル | J Neuroimmunol |
| Abstract |
We challenged to create a mouse model of neuromyelitis optica spectrum disorder (NMOSD) induced by AQP4 peptide immunization. Intradermal immunization with AQP4 p201-220 peptide induced paralysis in C57BL/6J mice, but not in AQP4 KO mice. AQP4 peptide-immunized mice showed pathological features similar to NMOSD. Administration of anti-IL-6 receptor antibody (MR16-1) inhibited the induction of clinical signs and prevented the loss of GFAP/AQP4 and deposition of complement factors in AQP4 peptide-immunized mice. This novel experimental model may contribute to further understanding the pathogenesis of NMOSD, elucidating the mechanism of action of therapeutic agents, and developing new therapeutic approaches. |
| 巻・号 | 380 |
| ページ | 578109 |
| 公開日 | 2023-7-15 |
| DOI | 10.1016/j.jneuroim.2023.578109 |
| PII | S0165-5728(23)00095-4 |
| PMID | 37210799 |
| MeSH | Animals Aquaporin 4 Autoantibodies Immunization Mice Mice, Inbred C57BL Neuromyelitis Optica* Peptides |
| IF | 3.125 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC10053 |