RRC ID 75051
Author Hutto RA, Rutter KM, Giarmarco MM, Parker ED, Chambers ZS, Brockerhoff SE.
Title Cone photoreceptors transfer damaged mitochondria to Müller glia.
Journal Cell Rep
Abstract Mitochondria are vital organelles that require sophisticated homeostatic mechanisms for maintenance. Intercellular transfer of damaged mitochondria is a recently identified strategy broadly used to improve cellular health and viability. Here, we investigate mitochondrial homeostasis in the vertebrate cone photoreceptor, the specialized neuron that initiates our daytime and color vision. We find a generalizable response to mitochondrial stress that leads to loss of cristae, displacement of damaged mitochondria from their normal cellular location, initiation of degradation, and transfer to Müller glia cells, a key non-neuronal support cell in the retina. Our findings show transmitophagy from cones to Müller glia as a response to mitochondrial damage. Intercellular transfer of damaged mitochondria represents an outsourcing mechanism that photoreceptors use to support their specialized function.
Volume 42(2)
Pages 112115
Published 2023-2-15
DOI 10.1016/j.celrep.2023.112115
PII S2211-1247(23)00126-2
PMID 36795565
IF 8.109
DNA material mito-SRAI_pcDNA3 (RDB18223)