論文 - 詳細
| RRC ID | 75231 |
|---|---|
| 著者 | Uchiyama J, Akiyama M, Hase K, Kumagai Y, Kim YG. |
| タイトル | Gut microbiota reinforce host antioxidant capacity via the generation of reactive sulfur species. |
| ジャーナル | Cell Rep |
| Abstract |
Gut microbiota act beyond the gastrointestinal tract to regulate the physiology of the host. However, their contribution to the antioxidant capacity of the host remains largely understudied. In this study, we observe that gut bacteria increase the steady-state plasma levels of high-antioxidant molecules, reactive sulfur species (RSS), such as hydrogen sulfide and cysteine persulfide (CysSSH), in the host. Moreover, gut bacteria utilize cystine as a substrate to enzymatically produce CysSSH. Administration of cystine to mice increases their plasma levels of RSS and suppresses the concanavalin-A-induced oxidative stress and liver damage in a gut-microbiota-dependent manner. We find that gut bacteria belonging to the Lachnospiraceae and Ruminococcaceae families have a high capacity to produce RSS, requiring pyridoxal 5'-phosphate for their enzymatic reactions. Collectively, our data demonstrate that gut microbiota enhance the antioxidant capacity of the host through the generation of RSS. |
| 巻・号 | 38(10) |
| ページ | 110479 |
| 公開日 | 2022-3-8 |
| DOI | 10.1016/j.celrep.2022.110479 |
| PII | S2211-1247(22)00212-1 |
| PMID | 35263581 |
| MeSH | Animals Antioxidants Bacteria Cystine Gastrointestinal Microbiome* Humans Hydrogen Sulfide* Mice Sulfur |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 32 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 15631 JCM 11019 JCM 9498 JCM 13471 JCM 13345 JCM 13265 JCM 5824 JCM 9496 JCM 5827 JCM 5828 JCM 5826 JCM 14655 JCM 1297 JCM 14986 JCM 15734 JCM 12243 JCM 1380 JCM 10188 JCM 31264 JCM 31256 JCM 11232 JCM 1429 JCM 1112 JCM 1717 JCM 5825 JCM 13406 JCM 9497 JCM 32126 JCM 6515 |