| RRC ID |
75249
|
| 著者 |
Li Z, Li Y, Li S, Li Z, Mai Y, Cheng J, Su D, Zhan Y, Zhong N, Ye F.
|
| タイトル |
Identification of a novel drug-resistant community-acquired Nocardia spp. in a patient with bronchiectasis.
|
| ジャーナル |
Emerg Microbes Infect
|
| Abstract |
A previously unknown Nocardia species was isolated from the lung tissue and bronchoalveolar lavage fluid (BALF) of a 58-year-old woman with bronchiectasis and recurrent pneumonia. This Nocardia (GZ2020T), which grew readily in Columbia blood agar and could induce pneumonia in a mouse model, represents a novel Nocardia species, and its closest known relatives are Nocardia anaemiae NBRC 100462T, Nocardia pseudovaccinii NBRC 100343T and Nocardia vinacea NBRC 16497T. However, unlike all previously known species, GZ2020T is the first genus of Nocardia spp. that is not susceptible to multiple drugs but does show susceptibility to linezolid and moxifloxacin, and thus, GZ2020T potentially represents a substantial health threat to patients with bronchiectasis and immunocompromised individuals. Although the original pathogen source and method of spreading remain uncertain, a mode of transmission from the environment to humans could exist. Vigilance with respect to its spread in the population and the transmission of antibiotic resistance genes in the environment should be maintained.
|
| 巻・号 |
11(1)
|
| ページ |
1346-1355
|
| 公開日 |
2022-12-1
|
| DOI |
10.1080/22221751.2022.2069514
|
| PMID |
35450515
|
| PMC |
PMC9132467
|
| MeSH |
Animals
Bronchiectasis* / epidemiology
Humans
Immunocompromised Host
Mice
Nocardia* / genetics
Nocardia Infections* / drug therapy
Nocardia Infections* / epidemiology
Pneumonia*
|
| リソース情報 |
| 一般微生物 |
JCM 34519 |
