論文 - 詳細
| RRC ID | 75480 |
|---|---|
| 著者 | Misaki Y, Takahashi Y, Hara K, Tatsuno S, Arakawa K. |
| タイトル | Three 4-monosubstituted butyrolactones from a regulatory gene mutant of Streptomyces rochei 7434AN4. |
| ジャーナル | J Biosci Bioeng |
| Abstract |
Extensive metabolite analysis of Streptomyces rochei 7434AN4 was performed to discover uncharacterized secondary metabolites. A mutant strain of S. rochei, in which two regulatory genes srrC (a tetR-type repressor) and srrY (SARP-type activator) were inactivated, accumulated three 4-monosubstituted γ-butyrolactones YT02-A, YT02-B, and KH01-A, which were not detected in the parent strain. Their structures were identified as 4,10-dihydroxy-10-methyldodecan-4-olide, 4,10-dihydroxy-10-methylundecan-4-olide, and 4-hydroxy-11-oxo-10-methyldodecan-4-olide. A structural comparison indicated that the three butanolides and the signaling molecules, termed S. rochei butenolides (SRBs), could share common C12 or C13 fatty acids for their biosynthesis intermediates, however, these three butanolides did not induce antibiotic production even at 50 μM concentration (1000-folds of the minimum antibiotic-inducing concentration of SRBs) in S. rochei. |
| 巻・号 | 133(4) |
| ページ | 329-334 |
| 公開日 | 2022-4-1 |
| DOI | 10.1016/j.jbiosc.2022.01.006 |
| PII | S1389-1723(22)00006-8 |
| PMID | 35123882 |
| MeSH | 4-Butyrolactone Anti-Bacterial Agents Bacterial Proteins / genetics Bacterial Proteins / metabolism Gene Expression Regulation, Bacterial Genes, Regulator Protein Binding Streptomyces* / genetics Streptomyces* / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 5070 |