論文 - 詳細
| RRC ID | 75523 |
|---|---|
| 著者 | Moon SJ, Hwang J, Kang WK, Ahn JP, Kim HJ. |
| タイトル | Administration of the probiotic Lactiplantibacillus paraplantarum is effective in controlling hyperphosphatemia in 5/6 nephrectomy rat model. |
| ジャーナル | Life Sci |
| Abstract |
AIMS:Several studies have linked gut microbes to human diseases. Most of the mechanisms by which lactic acid bacteria have beneficial effects on the human body are related to immune modulation. Controlled studies of the ability of lactic acid bacteria to absorb phosphorus directly from the intestine and thereby control serum phosphorus level in in vivo uremic animal models are limited. MATERIALS AND METHODS:We screened lactic acid bacteria living in Korean fermented foods to identify those that absorb the most phosphorus and noted Lactiplantibacillus paraplantarum KCCM 11826P. The mechanism through which better intracellular absorption of phosphorus occurs in this strain was studied using genomic DNA sequencing. After the strain was administered to 5/6 nephrectomized rats for 6 weeks, it was observed whether hyperphosphatemia had improved. KEY FINDINGS:The L. paraplantarum KCCM 11826P strain has a polyP gene cluster; thus, it absorbs phosphorus better than other bacteria and can suppress strains that produce indole. Supplementing the diets of 5/6 nephrectomized rats with this L. paraplantarum strain significantly decreased serum phosphate level (by 22 %) and reduced blood indoxyl sulphate concentration (by 40 %) compared with vehicle treatment. SIGNIFICANCE:These results suggest that Lactiplantibacillus preparations can be used for multiple purposes, such as the removal of phosphorus and uremic toxins from patients with chronic kidney disease (CKD). This study also demonstrates the novel concept of a probiotic phosphate binder. |
| 巻・号 | 306 |
| ページ | 120856 |
| 公開日 | 2022-10-1 |
| DOI | 10.1016/j.lfs.2022.120856 |
| PII | S0024-3205(22)00556-2 |
| PMID | 35926592 |
| MeSH | Animals Humans Hyperphosphatemia* Lactobacillus Nephrectomy Phosphates Phosphorus Probiotics* Rats Renal Insufficiency, Chronic* / therapy |
| リソース情報 | |
| 一般微生物 | JCM 1134 |