論文 - 詳細
| RRC ID | 75574 |
|---|---|
| 著者 | Hosomi K, Saito M, Park J, Murakami H, Shibata N, Ando M, Nagatake T, Konishi K, Ohno H, Tanisawa K, Mohsen A, Chen YA, Kawashima H, Natsume-Kitatani Y, Oka Y, Shimizu H, Furuta M, Tojima Y, Sawane K, Saika A, Kondo S, Yonejima Y, Takeyama H, Matsutani A, Mizuguchi K, Miyachi M, Kunisawa J. |
| タイトル | Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota. |
| ジャーナル | Nat Commun |
| Abstract |
The gut microbiome is an important determinant in various diseases. Here we perform a cross-sectional study of Japanese adults and identify the Blautia genus, especially B. wexlerae, as a commensal bacterium that is inversely correlated with obesity and type 2 diabetes mellitus. Oral administration of B. wexlerae to mice induce metabolic changes and anti-inflammatory effects that decrease both high-fat diet-induced obesity and diabetes. The beneficial effects of B. wexlerae are correlated with unique amino-acid metabolism to produce S-adenosylmethionine, acetylcholine, and L-ornithine and carbohydrate metabolism resulting in the accumulation of amylopectin and production of succinate, lactate, and acetate, with simultaneous modification of the gut bacterial composition. These findings reveal unique regulatory pathways of host and microbial metabolism that may provide novel strategies in preventive and therapeutic approaches for metabolic disorders. |
| 巻・号 | 13(1) |
| ページ | 4477 |
| 公開日 | 2022-8-18 |
| DOI | 10.1038/s41467-022-32015-7 |
| PII | 10.1038/s41467-022-32015-7 |
| PMID | 35982037 |
| PMC | PMC9388534 |
| MeSH | Acetylcholine Administration, Oral Adult Amylopectin Animals Carbohydrate Metabolism* Clostridiales* / metabolism Cross-Sectional Studies Diabetes Mellitus, Type 2* / microbiology Diabetes Mellitus, Type 2* / therapy Diet, High-Fat / adverse effects Gastrointestinal Microbiome* / physiology Humans Japan Mice Mice, Inbred C57BL Obesity* / microbiology Obesity* / therapy Ornithine Symbiosis |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 76 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.5 |
| リソース情報 | |
| 一般微生物 | JCM 17041 JCM 5826 JCM 13464 JCM 31915 JCM 31056 |