| RRC ID |
75580
|
| Author |
Kondo T, Yasui C, Miyajima I, Banno T, Asakura K, Fukuoka T, Ushimaru K, Koga M, Saika A, Morita T, Takahashi Y, Hayashi C, Igarashi M, Takahashi D, Toshima K.
|
| Title |
Synthesis of Mannosylerythritol Lipid Analogues and their Self-Assembling Properties, Recovery Effects on Damaged Skin Cells, and Antibacterial Activity.
|
| Journal |
Chemistry
|
| Abstract |
Synthesis of three types of purpose-designed mannosylerythritol lipid (MEL)-D analogues with decanoyl groups, β-GlcEL-D, α-GlcEL-D, and α-MEL-D, was accomplished utilizing our boron-mediated aglycon delivery (BMAD) methods. Their self-assembling properties, recovery effects on damaged skin cells, and antibacterial activity were evaluated. It was revealed, for the first time, that α-GlcEL-D and α-MEL-D only generated giant vesicles, indicating that slight differences in the steric configuration of an erythritol moiety and fatty acyl chains affect the ability to form vesicles. Analogue α-MEL-D exhibited significant recovery effects on damaged skin cells. Furthermore, α-MEL-D exhibited antibacterial activity as high as that for MEL-D, indicating that α-MEL-D is a promising artificial sugar-based material candidate for enhancing the barrier function of the stratum corneum, superior to a known cosmetic ingredient, and possesses antibacterial activity.
|
| Volume |
28(55)
|
| Pages |
e202201733
|
| Published |
2022-10-4
|
| DOI |
10.1002/chem.202201733
|
| PMID |
35761481
|
| MeSH |
Anti-Bacterial Agents / pharmacology
Boron*
Erythritol
Glycolipids
Sugars
Surface-Active Agents* / pharmacology
|
| Resource |
| General Microbes |
JCM 5803
JCM 5804 |
