| RRC ID |
75611
|
| Author |
Tsukatani T, Kuroda R, Kawaguchi T.
|
| Title |
Screening biofilm eradication activity of ethanol extracts from foodstuffs: potent biofilm eradication activity of glabridin, a major flavonoid from licorice (Glycyrrhiza glabra), alone and in combination with ɛ-poly-L-lysine.
|
| Journal |
World J Microbiol Biotechnol
|
| Abstract |
The ethanol extracts of 155 different foodstuffs containing medicinal plants were investigated for their biofilm eradication activities against pathogenic bacteria. A combined method of a colorimetric microbial viability assay based on reduction of a tetrazolium salt (WST-8) and a biofilm formation technique on the 96-pins of a microtiter plate lid was used to screen the biofilm eradication activities of foodstuffs. The ethanol extracts of licorice (Glycyrrhiza glabra) showed potent biofilm eradication activities against Streptococcus mutans, Staphylococcus aureus, and Porphyromonas gingivalis. Among the antimicrobial constituents in licorice, glabridin had the most potent eradication activities against microbial biofilms. The minimum biofilm eradication concentration of glabridin was 25-50 μg/ml. Furthermore, the combination of glabridin with ɛ-poly-L-lysine, a food additive, could result in broad biofilm eradication activities towards a wide variety of bacteria associated with infection, including Escherichia coli and Pseudomonas aeruginosa.
|
| Volume |
38(2)
|
| Pages |
24
|
| Published |
2022-1-6
|
| DOI |
10.1007/s11274-021-03206-z
|
| PII |
10.1007/s11274-021-03206-z
|
| PMID |
34989883
|
| MeSH |
Anti-Bacterial Agents / pharmacology
Biofilms / drug effects*
Ethanol
Flavonoids / pharmacology*
Food Additives
Glycyrrhiza / chemistry*
Isoflavones / pharmacology*
Microbial Sensitivity Tests
Microbial Viability / drug effects
Phenols / pharmacology*
Plant Extracts / pharmacology*
Polylysine / pharmacology*
Porphyromonas gingivalis / drug effects
Pseudomonas aeruginosa / drug effects
Staphylococcus aureus / drug effects
Streptococcus mutans / drug effects
|
| Resource |
| General Microbes |
JCM 12257 |
