| RRC ID |
75729
|
| 著者 |
Watanabe K, Oka T, Takagi H, Anisimov S, Yamashita SI, Katsuragi Y, Takahashi M, Higuchi M, Kanki T, Saitoh A, Fujii M.
|
| タイトル |
Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry.
|
| ジャーナル |
Nat Commun
|
| Abstract |
Human parechovirus (PeV-A) is an RNA virus that belongs to the family Picornaviridae and it is currently classified into 19 genotypes. PeV-As usually cause mild illness in children and adults. Among the genotypes, PeV-A3 can cause severe diseases in neonates and young infants, resulting in neurological sequelae and death. In this study, we identify the human myeloid-associated differentiation marker (MYADM) as an essential host factor for the entry of six PeV-As (PeV-A1 to PeV-A6), including PeV-A3. The infection of six PeV-As (PeV-A1 to PeV-A6) to human cells is abolished by knocking out the expression of MYADM. Hamster BHK-21 cells are resistant to PeV-A infection, but the expression of human MYADM in BHK-21 confers PeV-A infection and viral production. Furthermore, VP0 capsid protein of PeV-A3 interacts with one extracellular domain of human MYADM on the cell membrane of BHK-21. The identification of MYADM as an essential entry factor for PeV-As infection is expected to advance our understanding of the pathogenesis of PeV-As.
|
| 巻・号 |
14(1)
|
| ページ |
1817
|
| 公開日 |
2023-3-31
|
| DOI |
10.1038/s41467-023-37399-8
|
| PII |
10.1038/s41467-023-37399-8
|
| PMID |
37002207
|
| PMC |
PMC10066301
|
| MeSH |
Adult
Antigens, Differentiation
Child
Genotype
Humans
Infant
Infant, Newborn
Parechovirus* / genetics
Picornaviridae*
Picornaviridae Infections*
|
| IF |
12.121
|
| リソース情報 |
| 遺伝子材料 |
CSII-EF-MCS (RDB04378)
pCMV-VSV-G-RSV-Rev (RDB04393)
pCAG-HIVgp (RDB04394) |
