論文 - 詳細
| RRC ID | 75729 |
|---|---|
| 著者 | Watanabe K, Oka T, Takagi H, Anisimov S, Yamashita SI, Katsuragi Y, Takahashi M, Higuchi M, Kanki T, Saitoh A, Fujii M. |
| タイトル | Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry. |
| ジャーナル | Nat Commun |
| Abstract |
Human parechovirus (PeV-A) is an RNA virus that belongs to the family Picornaviridae and it is currently classified into 19 genotypes. PeV-As usually cause mild illness in children and adults. Among the genotypes, PeV-A3 can cause severe diseases in neonates and young infants, resulting in neurological sequelae and death. In this study, we identify the human myeloid-associated differentiation marker (MYADM) as an essential host factor for the entry of six PeV-As (PeV-A1 to PeV-A6), including PeV-A3. The infection of six PeV-As (PeV-A1 to PeV-A6) to human cells is abolished by knocking out the expression of MYADM. Hamster BHK-21 cells are resistant to PeV-A infection, but the expression of human MYADM in BHK-21 confers PeV-A infection and viral production. Furthermore, VP0 capsid protein of PeV-A3 interacts with one extracellular domain of human MYADM on the cell membrane of BHK-21. The identification of MYADM as an essential entry factor for PeV-As infection is expected to advance our understanding of the pathogenesis of PeV-As. |
| 巻・号 | 14(1) |
| ページ | 1817 |
| 公開日 | 2023-3-31 |
| DOI | 10.1038/s41467-023-37399-8 |
| PII | 10.1038/s41467-023-37399-8 |
| PMID | 37002207 |
| PMC | PMC10066301 |
| MeSH | Adult Antigens, Differentiation Child Genotype Humans Infant Infant, Newborn Parechovirus* / genetics Picornaviridae* Picornaviridae Infections* |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 20 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | CSII-EF-MCS (RDB04378) pCMV-VSV-G-RSV-Rev (RDB04393) pCAG-HIVgp (RDB04394) |