| RRC ID |
75799
|
| 著者 |
Mimura T, Takeuchi K, Hiramatsu K, Tsujikawa K, Kohama Y, Itoh S.
|
| タイトル |
Pharmacological activity of chemically modified subfragment from human serum IgG. XIV. Inhibitory effect of carboxamide-methylated light chain (G1L) on tyrosine phosphorylation and tumor necrosis factor-alpha production from murine macrophages stimulated by lipopolysaccharide.
|
| ジャーナル |
Biol Pharm Bull
|
| Abstract |
Carboxamide-methylated light chain (G1L) from human serum IgG inhibited the secretion of tumor necrosis factor (TNF-alpha), one of the inflammatory cytokines, from adherent splenocytes and thioglycolate-induced peritoneal macrophages. The inhibition of TNF-alpha secretion by G1L was associated with disappearance of tyrosine phosphorylation on about 40 kDa protein when thioglycolate-induced peritoneal macrophages were stimulated with lipopolysaccharide (LPS). It is possible that this G1L anti-inflammatory activity occurs through the blockage of the phosphorylation of about 40 kDa protein.
|
| 巻・号 |
18(10)
|
| ページ |
1377-81
|
| 公開日 |
1995-10-1
|
| DOI |
10.1248/bpb.18.1377
|
| PMID |
8593440
|
| MeSH |
Animals
Blotting, Western
Cell Adhesion / drug effects
Cell Line
Cell Survival / drug effects
Endotoxins / pharmacology
Humans
Immunoglobulin G / chemistry
Immunoglobulin G / pharmacology*
Immunoglobulin Light Chains / chemistry
Immunoglobulin Light Chains / pharmacology*
Lipopolysaccharides / pharmacology*
Macrophages / drug effects
Macrophages / metabolism*
Macrophages, Peritoneal / drug effects
Macrophages, Peritoneal / metabolism
Male
Methylation
Mice
Mice, Inbred ICR
Phosphorylation
Protein-Tyrosine Kinases / antagonists & inhibitors
Protein-Tyrosine Kinases / metabolism
Spleen / cytology
Spleen / drug effects
Spleen / metabolism
T-Lymphocytes / drug effects
T-Lymphocytes / metabolism
Tumor Necrosis Factor-alpha / biosynthesis*
Tyrosine / metabolism*
|
| IF |
1.863
|
| リソース情報 |
| ヒト・動物細胞 |
L929(RCB0081) |
