論文 - 詳細
| RRC ID | 75828 |
|---|---|
| 著者 | Ting TY, Li Y, Bunawan H, Ramzi AB, Goh HH. |
| タイトル | Current advancements in systems and synthetic biology studies of Saccharomyces cerevisiae. |
| ジャーナル | J Biosci Bioeng |
| Abstract |
Saccharomyces cerevisiae has a long-standing history of biotechnological applications even before the dawn of modern biotechnology. The field is undergoing accelerated advancement with the recent systems and synthetic biology approaches. In this review, we highlight the recent findings in the field with a focus on omics studies of S. cerevisiae to investigate its stress tolerance in different industries. The latest advancements in S. cerevisiae systems and synthetic biology approaches for the development of genome-scale metabolic models (GEMs) and molecular tools such as multiplex Cas9, Cas12a, Cpf1, and Csy4 genome editing tools, modular expression cassette with optimal transcription factors, promoters, and terminator libraries as well as metabolic engineering. Omics data analysis is key to the identification of exploitable native genes/proteins/pathways in S. cerevisiae with the optimization of heterologous pathway implementation and fermentation conditions. Through systems and synthetic biology, various heterologous compound productions that require non-native biosynthetic pathways in a cell factory have been established via different strategies of metabolic engineering integrated with machine learning. |
| 巻・号 | 135(4) |
| ページ | 259-265 |
| 公開日 | 2023-4-1 |
| DOI | 10.1016/j.jbiosc.2023.01.010 |
| PII | S1389-1723(23)00027-0 |
| PMID | 36803862 |
| MeSH | Biosynthetic Pathways Gene Editing Metabolic Engineering Saccharomyces cerevisiae* / genetics Saccharomyces cerevisiae* / metabolism Synthetic Biology* |
| IF | 2.366 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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