論文 - 詳細
| RRC ID | 75880 |
|---|---|
| 著者 | Wen H, Eckenstein K, Weihrauch V, Stigloher C, Brehm P. |
| タイトル | Primary and secondary motoneurons use different calcium channel types to control escape and swimming behaviors in zebrafish. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
The escape response and rhythmic swimming in zebrafish are distinct behaviors mediated by two functionally distinct motoneuron (Mn) types. The primary (1°Mn) type depresses and has a large quantal content (Qc) and a high release probability (Pr). Conversely, the secondary (2°Mn) type facilitates and has low and variable Qc and Pr. This functional duality matches well the distinct associated behaviors, with the 1°Mn providing the strong, singular C bend initiating escape and the 2°Mn conferring weaker, rhythmic contractions. Contributing to these functional distinctions is our identification of P/Q-type calcium channels mediating transmitter release in 1°Mns and N-type channels in 2°Mns. Remarkably, despite these functional and behavioral distinctions, all ∼15 individual synapses on each muscle cell are shared by a 1°Mn bouton and at least one 2°Mn bouton. This blueprint of synaptic sharing provides an efficient way of controlling two different behaviors at the level of a single postsynaptic cell. |
| 巻・号 | 117(42) |
| ページ | 26429-26437 |
| 公開日 | 2020-10-20 |
| DOI | 10.1073/pnas.2015866117 |
| PII | 2015866117 |
| PMID | 33020266 |
| PMC | PMC7585033 |
| MeSH | Animals Calcium / metabolism Calcium Channels / metabolism* Calcium Channels / physiology* Calcium Channels, N-Type / metabolism Calcium Channels, P-Type / metabolism Calcium Channels, Q-Type / metabolism Escape Reaction / physiology Motor Neurons / metabolism* Motor Neurons / physiology Neuromuscular Junction / metabolism Presynaptic Terminals / physiology Swimming / physiology Synapses / metabolism Zebrafish / metabolism |
| IF | 9.412 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ゼブラフィッシュ | SAIGFF213A UAS:GFP |