論文 - 詳細
| RRC ID | 75893 |
|---|---|
| 著者 | Miura T, Ohno N, Miura NN, Shimada S, Yadomae T. |
| タイトル | Inactivation of a particle beta-glucan by proteins in plasma and serum. |
| ジャーナル | Biol Pharm Bull |
| Abstract |
(1-->3)-beta-D-Glucans remained in the liver and spleen for long time, i.e. more than a month, without major structural changes/because there is no specific metabolic pathway for it in the body. However, biological activities, such as priming activity to LPS, triggered TNF-alpha synthesis, and antitumor activity was reduced more quickly. In this paper, we demonstrated the contribution of protein binding in inactivating beta-glucans. A particle beta-glucan preparation, zymosan, was treated with serum or plasma at 37 degrees C and their various biological activities were compared with zymosan alone. Such biological activities as antitumor activity, TNF-production, IL-6 production, complement activation and vascular permeability were significantly decreased by serum or plasma treatment. These results strongly suggested that the binding of serum or plasma protein(s) to beta-glucans would be a key step in inactivating a particle beta-glucan in the body. |
| 巻・号 | 20(10) |
| ページ | 1103-7 |
| 公開日 | 1997-10-1 |
| DOI | 10.1248/bpb.20.1103 |
| PMID | 9353573 |
| MeSH | Animals Antineoplastic Agents / blood* Antineoplastic Agents / metabolism Antineoplastic Agents / pharmacology Blood Proteins / metabolism* Capillary Permeability / drug effects Complement System Proteins / metabolism Erythrocytes / drug effects Erythrocytes / metabolism Humans Interleukin-6 / metabolism Liver / drug effects Macrophages, Peritoneal / drug effects Macrophages, Peritoneal / metabolism Male Mice Mice, Inbred ICR Neoplasm Transplantation Organ Size / drug effects Rabbits Sarcoma 180 / pathology Spleen / drug effects Tumor Necrosis Factor-alpha / metabolism Zymosan / blood* Zymosan / metabolism Zymosan / pharmacology |
| IF | 1.863 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |