論文 - 詳細
| RRC ID | 75980 |
|---|---|
| 著者 | Jeong H, Park JY, Lee JH, Baik JH, Kim CY, Cho JY, Driscoll M, Paik YK. |
| タイトル | Deficiency in RCAT-1 Function Causes Dopamine Metabolism Related Behavioral Disorders in Caenorhabditis elegans. |
| ジャーナル | Int J Mol Sci |
| Abstract |
When animals are faced with food depletion, food search-associated locomotion is crucial for their survival. Although food search-associated locomotion is known to be regulated by dopamine, it has yet to investigate the potential molecular mechanisms governing the regulation of genes involved in dopamine metabolism (e.g., cat-1, cat-2) and related behavioral disorders. During the studies of the pheromone ascaroside, a signal of starvation stress in C. elegans, we identified R02D3.7, renamed rcat-1 (regulator of cat genes-1), which had previously been shown to bind to regulatory sequences of both cat-1 and cat-2 genes. It was found that RCAT-1 (R02D3.7) is expressed in dopaminergic neurons and functions as a novel negative transcriptional regulator for cat-1 and cat-2 genes. When a food source becomes depleted, the null mutant, rcat-1(ok1745), exhibited an increased frequency of high-angled turns and intensified area restricted search behavior compared to the wild-type animals. Moreover, rcat-1(ok1745) also showed defects in state-dependent olfactory adaptation and basal slowing response, suggesting that the mutants are deficient in either sensing food or locomotion toward food. However, rcat-1(ok1745) has normal cuticular structures and locomotion genes. The discovery of rcat-1 not only identifies a new subtype of dopamine-related behaviors but also provides a potential therapeutic target in Parkinson's disease. |
| 巻・号 | 23(4) |
| 公開日 | 2022-2-21 |
| DOI | 10.3390/ijms23042393 |
| PII | ijms23042393 |
| PMID | 35216508 |
| PMC | PMC8879058 |
| MeSH | Animals Animals, Genetically Modified / metabolism Behavior, Animal / physiology* Caenorhabditis elegans / metabolism* Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism* Dopamine / metabolism* Dopaminergic Neurons / metabolism Gene Expression Regulation / physiology Locomotion / physiology Pheromones / metabolism Signal Transduction / physiology |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm4063 |