論文 - 詳細
| RRC ID | 76034 |
|---|---|
| 著者 | Prakash D, Ms A, Radhika B, Venkatesan R, Chalasani SH, Singh V. |
| タイトル | 1-Undecene from Pseudomonas aeruginosa is an olfactory signal for flight-or-fight response in Caenorhabditis elegans. |
| ジャーナル | EMBO J |
| Abstract |
Animals possess conserved mechanisms to detect pathogens and to improve survival in their presence by altering their own behavior and physiology. Here, we utilize Caenorhabditis elegans as a model host to ask whether bacterial volatiles constitute microbe-associated molecular patterns. Using gas chromatography-mass spectrometry, we identify six prominent volatiles released by the bacterium Pseudomonas aeruginosa. We show that a specific volatile, 1-undecene, activates nematode odor sensory neurons inducing both flight and fight responses in worms. Using behavioral assays, we show that worms are repelled by 1-undecene and that this aversion response is driven by the detection of this volatile through AWB odor sensory neurons. Furthermore, we find that 1-undecene odor can induce immune effectors specific to P. aeruginosa via AWB neurons and that brief pre-exposure of worms to the odor enhances their survival upon subsequent bacterial infection. These results show that 1-undecene derived from P. aeruginosa serves as a pathogen-associated molecular pattern for the induction of protective responses in C. elegans. |
| 巻・号 | 40(13) |
| ページ | e106938 |
| 公開日 | 2021-7-1 |
| DOI | 10.15252/embj.2020106938 |
| PMID | 34086368 |
| PMC | PMC8246062 |
| MeSH | Animals Caenorhabditis elegans / metabolism* Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism* Host-Pathogen Interactions / physiology Odorants Pseudomonas aeruginosa / metabolism* Sensory Receptor Cells / metabolism Sensory Receptor Cells / physiology Signal Transduction / physiology |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 46 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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| 線虫 | tm4248 |