論文 - 詳細
| RRC ID | 76043 |
|---|---|
| 著者 | Reilly DK, McGlame EJ, Vandewyer E, Robidoux AN, Muirhead CS, Northcott HT, Joyce W, Alkema MJ, Gegear RJ, Beets I, Srinivasan J. |
| タイトル | Distinct neuropeptide-receptor modules regulate a sex-specific behavioral response to a pheromone. |
| ジャーナル | Commun Biol |
| Abstract |
Dioecious species are a hallmark of the animal kingdom, with opposing sexes responding differently to identical sensory cues. Here, we study the response of C. elegans to the small-molecule pheromone, ascr#8, which elicits opposing behavioral valences in each sex. We identify a novel neuropeptide-neuropeptide receptor (NP/NPR) module that is active in males, but not in hermaphrodites. Using a novel paradigm of neuropeptide rescue that we established, we leverage bacterial expression of individual peptides to rescue the sex-specific response to ascr#8. Concurrent biochemical studies confirmed individual FLP-3 peptides differentially activate two divergent receptors, NPR-10 and FRPR-16. Interestingly, the two of the peptides that rescued behavior in our feeding paradigm are related through a conserved threonine, suggesting that a specific NP/NPR combination sets a male state, driving the correct behavioral valence of the ascr#8 response. Receptor expression within pre-motor neurons reveals novel coordination of male-specific and core locomotory circuitries. |
| 巻・号 | 4(1) |
| ページ | 1018 |
| 公開日 | 2021-8-31 |
| DOI | 10.1038/s42003-021-02547-7 |
| PII | 10.1038/s42003-021-02547-7 |
| PMID | 34465863 |
| PMC | PMC8408276 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins Carrier Proteins Hermaphroditic Organisms / genetics Hermaphroditic Organisms / physiology* Locomotion* / drug effects Male Receptors, Neuropeptide / genetics* Receptors, Neuropeptide / metabolism |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm8982 tm1782 tm272 |