論文 - 詳細
| RRC ID | 76086 |
|---|---|
| 著者 | Wallace SW, Lizzappi MC, Magemizoğlu E, Hur H, Liang Y, Shaham S. |
| タイトル | Nuclear hormone receptors promote gut and glia detoxifying enzyme induction and protect C. elegans from the mold P. brevicompactum. |
| ジャーナル | Cell Rep |
| Abstract |
Animals encounter microorganisms in their habitats, adapting physiology and behavior accordingly. The nematode Caenorhabditis elegans is found in microbe-rich environments; however, its responses to fungi are not extensively studied. Here, we describe interactions of C. elegans and Penicillium brevicompactum, an ecologically relevant mold. Transcriptome studies reveal that co-culture upregulates stress response genes, including xenobiotic-metabolizing enzymes (XMEs), in C. elegans intestine and AMsh glial cells. The nuclear hormone receptors (NHRs) NHR-45 and NHR-156 are induction regulators, and mutants that cannot induce XMEs in the intestine when exposed to P. brevicompactum experience mitochondrial stress and exhibit developmental defects. Different C. elegans wild isolates harbor sequence polymorphisms in nhr-156, resulting in phenotypic diversity in AMsh glia responses to microbe exposure. We propose that P. brevicompactum mitochondria-targeting mycotoxins are deactivated by intestinal detoxification, allowing tolerance to moldy environments. Our studies support the idea that C. elegans NHRs may be regulated by environmental cues. |
| 巻・号 | 37(13) |
| ページ | 110166 |
| 公開日 | 2021-12-28 |
| DOI | 10.1016/j.celrep.2021.110166 |
| PII | S2211-1247(21)01666-1 |
| PMID | 34965433 |
| PMC | PMC8733895 |
| MeSH | Animals Caenorhabditis elegans / drug effects* Caenorhabditis elegans / enzymology Caenorhabditis elegans / microbiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Enzyme Induction Gastrointestinal Tract / drug effects Gastrointestinal Tract / enzymology* Gastrointestinal Tract / microbiology Gene Expression Regulation, Developmental Mitochondria / drug effects Mitochondria / enzymology* Mitochondria / microbiology Neuroglia / drug effects Neuroglia / enzymology* Neuroglia / microbiology Penicillium / physiology* Receptors, Cytoplasmic and Nuclear / metabolism* |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1307 tm1819 |