論文 - 詳細
| RRC ID | 76108 |
|---|---|
| 著者 | Zheng Z, Aihemaiti Y, Liu J, Afridi MI, Yang S, Zhang X, Xu Y, Chen C, Tu H. |
| タイトル | The bZIP Transcription Factor ZIP-11 Is Required for the Innate Immune Regulation in Caenorhabditis elegans. |
| ジャーナル | Front Immunol |
| Abstract |
Innate immunity is the first line of host defense against pathogen infection in metazoans. However, the molecular mechanisms of the complex immune regulatory network are not fully understood. Based on a transcriptome profiling of the nematode Caenorhabditis elegans, we found that a bZIP transcription factor ZIP-11 was up-regulated upon Pseudomonas aeruginosa PA14 infection. The tissue specific RNAi knock-down and rescue data revealed that ZIP-11 acts in intestine to promote host resistance against P. aeruginosa PA14 infection. We further showed that intestinal ZIP-11 regulates innate immune response through constituting a feedback loop with the conserved PMK-1/p38 mitogen-activated protein signaling pathway. Intriguingly, ZIP-11 interacts with a CCAAT/enhancer-binding protein, CEBP-2, to mediate the transcriptional response to P. aeruginosa PA14 infection independently of PMK-1/p38 pathway. In addition, human homolog ATF4 can functionally substitute for ZIP-11 in innate immune regulation of C. elegans. Our findings indicate that the ZIP-11/ATF4 genetic program activates local innate immune response through conserved PMK-1/p38 and CEBP-2/C/EBPγ immune signals in C. elegans, raising the possibility that a similar process may occur in other organisms. |
| 巻・号 | 12 |
| ページ | 744454 |
| 公開日 | 2021-1-1 |
| DOI | 10.3389/fimmu.2021.744454 |
| PMID | 34804026 |
| PMC | PMC8602821 |
| MeSH | Activating Transcription Factor 4 / immunology Animals Animals, Genetically Modified Basic-Leucine Zipper Transcription Factors / immunology* Caenorhabditis elegans / immunology Caenorhabditis elegans Proteins / immunology* Humans Immunity, Innate / immunology* |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm4554 tm5421 |