| RRC ID |
76108
|
| 著者 |
Zheng Z, Aihemaiti Y, Liu J, Afridi MI, Yang S, Zhang X, Xu Y, Chen C, Tu H.
|
| タイトル |
The bZIP Transcription Factor ZIP-11 Is Required for the Innate Immune Regulation in Caenorhabditis elegans.
|
| ジャーナル |
Front Immunol
|
| Abstract |
Innate immunity is the first line of host defense against pathogen infection in metazoans. However, the molecular mechanisms of the complex immune regulatory network are not fully understood. Based on a transcriptome profiling of the nematode Caenorhabditis elegans, we found that a bZIP transcription factor ZIP-11 was up-regulated upon Pseudomonas aeruginosa PA14 infection. The tissue specific RNAi knock-down and rescue data revealed that ZIP-11 acts in intestine to promote host resistance against P. aeruginosa PA14 infection. We further showed that intestinal ZIP-11 regulates innate immune response through constituting a feedback loop with the conserved PMK-1/p38 mitogen-activated protein signaling pathway. Intriguingly, ZIP-11 interacts with a CCAAT/enhancer-binding protein, CEBP-2, to mediate the transcriptional response to P. aeruginosa PA14 infection independently of PMK-1/p38 pathway. In addition, human homolog ATF4 can functionally substitute for ZIP-11 in innate immune regulation of C. elegans. Our findings indicate that the ZIP-11/ATF4 genetic program activates local innate immune response through conserved PMK-1/p38 and CEBP-2/C/EBPγ immune signals in C. elegans, raising the possibility that a similar process may occur in other organisms.
|
| 巻・号 |
12
|
| ページ |
744454
|
| 公開日 |
2021-1-1
|
| DOI |
10.3389/fimmu.2021.744454
|
| PMID |
34804026
|
| PMC |
PMC8602821
|
| MeSH |
Activating Transcription Factor 4 / immunology
Animals
Animals, Genetically Modified
Basic-Leucine Zipper Transcription Factors / immunology*
Caenorhabditis elegans / immunology
Caenorhabditis elegans Proteins / immunology*
Humans
Immunity, Innate / immunology*
|
| リソース情報 |
| 線虫 |
tm4554
tm5421 |
