論文 - 詳細
| RRC ID | 76114 |
|---|---|
| 著者 | Aprison EZ, Dzitoyeva S, Angeles-Albores D, Ruvinsky I. |
| タイトル | A male pheromone that improves the quality of the oogenic germline. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Pheromones exchanged by conspecifics are a major class of chemical signals that can alter behavior, physiology, and development. In particular, males and females communicate with potential mating partners via sex pheromones to promote reproductive success. Physiological and developmental mechanisms by which pheromones facilitate progeny production remain largely enigmatic. Here, we describe how a Caenorhabditis elegans male pheromone, ascr#10, improves the oogenic germline. Before most signs of aging become evident, C. elegans hermaphrodites start producing lower-quality gametes characterized by abnormal morphology, increased rates of chromosomal nondisjunction, and higher penetrance of deleterious alleles. We show that exposure to the male pheromone substantially ameliorates these defects and reduces embryonic lethality. ascr#10 stimulates proliferation of germline precursor cells in adult hermaphrodites. Coupled to the greater precursor supply is increased physiological germline cell death, which is required to improve oocyte quality in older mothers. The hermaphrodite germline is sensitive to the pheromone only during a time window, comparable in duration to a larval stage, in early adulthood. During this period, prereproductive adults assess the suitability of the environment for reproduction. Our results identify developmental events that occur in the oogenic germline in response to a male pheromone. They also suggest that the opposite effects of the pheromone on gamete quality and maternal longevity arise from competition over resource allocation between soma and the germline. |
| 巻・号 | 119(21) |
| ページ | e2015576119 |
| 公開日 | 2022-5-24 |
| DOI | 10.1073/pnas.2015576119 |
| PMID | 35576466 |
| PMC | PMC9173808 |
| MeSH | Animals Caenorhabditis elegans* / growth & development Cellular Senescence* / drug effects Cellular Senescence* / physiology Female Male Oocytes* / drug effects Oocytes* / physiology Oogenesis* / drug effects Oogenesis* / physiology Sex Attractants* / pharmacology Sex Attractants* / physiology |
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オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 42 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1458 |