論文 - 詳細
| RRC ID | 76135 |
|---|---|
| 著者 | Cassani M, Seydoux G. |
| タイトル | Specialized germline P-bodies are required to specify germ cell fate in Caenorhabditis elegans embryos. |
| ジャーナル | Development |
| Abstract |
In animals with germ plasm, specification of the germline involves 'germ granules', cytoplasmic condensates that enrich maternal transcripts in the germline founder cells. In Caenorhabditis elegans embryos, P granules enrich maternal transcripts, but surprisingly P granules are not essential for germ cell fate specification. Here, we describe a second condensate in the C. elegans germ plasm. Like canonical P-bodies found in somatic cells, 'germline P-bodies' contain regulators of mRNA decapping and deadenylation and, in addition, the intrinsically-disordered proteins MEG-1 and MEG-2 and the TIS11-family RNA-binding protein POS-1. Embryos lacking meg-1 and meg-2 do not stabilize P-body components, misregulate POS-1 targets, mis-specify the germline founder cell and do not develop a germline. Our findings suggest that specification of the germ line involves at least two distinct condensates that independently enrich and regulate maternal mRNAs in the germline founder cells. This article has an associated 'The people behind the papers' interview. |
| 巻・号 | 149(21) |
| 公開日 | 2022-11-1 |
| DOI | 10.1242/dev.200920 |
| PII | 280972 |
| PMID | 36196602 |
| PMC | PMC9686995 |
| MeSH | Animals Caenorhabditis elegans* / genetics Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Cell Differentiation / genetics Cytoplasmic Granules / metabolism Germ Cells / metabolism Processing Bodies RNA-Binding Proteins / genetics RNA-Binding Proteins / metabolism |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 12 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm4259 |