論文 - 詳細
| RRC ID | 76141 |
|---|---|
| 著者 | Cheng D, Lee JS, Brown M, Ebert MS, McGrath PT, Tomioka M, Iino Y, Bargmann CI. |
| タイトル | Insulin/IGF signaling regulates presynaptic glutamate release in aversive olfactory learning. |
| ジャーナル | Cell Rep |
| Abstract |
Insulin/insulin-like growth factor (IGF) receptor signaling (IIS) supports context-dependent learning in vertebrates and invertebrates. Here, we identify cell-specific mechanisms of IIS that integrate sensory information with food context to drive synaptic plasticity and learning. In the nematode Caenorhabditis elegans, pairing food deprivation with an odor such as butanone suppresses attraction to that odor. We find that aversive olfactory learning requires the insulin receptor substrate (IRS) protein IST-1 and atypical signaling through the insulin/IGF-1 receptor DAF-2. Cell-specific knockout and rescue demonstrate that DAF-2 acts in the AWCON sensory neuron, which detects butanone, and that learning preferentially depends upon the axonally localized DAF-2c isoform. Acute food deprivation increases DAF-2 levels in AWCON post-transcriptionally through an insulin- and insulin receptor substrate-1 (ist-1)-dependent process. Aversive learning alters the synaptic output of AWCON by suppressing odor-regulated glutamate release in wild-type animals, but not in ist-1 mutants, suggesting that axonal insulin signaling regulates synaptic transmission to support aversive memory. |
| 巻・号 | 41(8) |
| ページ | 111685 |
| 公開日 | 2022-11-22 |
| DOI | 10.1016/j.celrep.2022.111685 |
| PII | S2211-1247(22)01559-5 |
| PMID | 36417877 |
| MeSH | Animals Butanones Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins* / metabolism Glutamic Acid Insulin / metabolism Sensory Receptor Cells / metabolism Somatomedins* |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 28 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2411 |