| RRC ID |
76183
|
| Author |
Handley A, Wu Q, Sherry T, Cornell R, Pocock R.
|
| Title |
Diet-responsive transcriptional regulation of insulin in a single neuron controls systemic metabolism.
|
| Journal |
PLoS Biol
|
| Abstract |
Metabolic homeostasis is coordinated through a robust network of signaling pathways acting across all tissues. A key part of this network is insulin-like signaling, which is fundamental for surviving glucose stress. Here, we show that Caenorhabditis elegans fed excess dietary glucose reduce insulin-1 (INS-1) expression specifically in the BAG glutamatergic sensory neurons. We demonstrate that INS-1 expression in the BAG neurons is directly controlled by the transcription factor ETS-5, which is also down-regulated by glucose. We further find that INS-1 acts exclusively from the BAG neurons, and not other INS-1-expressing neurons, to systemically inhibit fat storage via the insulin-like receptor DAF-2. Together, these findings reveal an intertissue regulatory pathway where regulation of insulin expression in a specific neuron controls systemic metabolism in response to excess dietary glucose.
|
| Volume |
20(5)
|
| Pages |
e3001655
|
| Published |
2022-5-1
|
| DOI |
10.1371/journal.pbio.3001655
|
| PII |
PBIOLOGY-D-21-02978
|
| PMID |
35594303
|
| PMC |
PMC9162364
|
| MeSH |
Animals
Caenorhabditis elegans / genetics
Caenorhabditis elegans / metabolism
Caenorhabditis elegans Proteins* / genetics
Caenorhabditis elegans Proteins* / metabolism
Diet
Forkhead Transcription Factors / metabolism
Glucose / metabolism
Insulin* / metabolism
Neurons / metabolism
Receptor, Insulin / genetics
Receptor, Insulin / metabolism
|
| Resource |
| C.elegans |
tm1734
tm1888 |
