Reference - Detail
| RRC ID | 76183 |
|---|---|
| Author | Handley A, Wu Q, Sherry T, Cornell R, Pocock R. |
| Title | Diet-responsive transcriptional regulation of insulin in a single neuron controls systemic metabolism. |
| Journal | PLoS Biol |
| Abstract |
Metabolic homeostasis is coordinated through a robust network of signaling pathways acting across all tissues. A key part of this network is insulin-like signaling, which is fundamental for surviving glucose stress. Here, we show that Caenorhabditis elegans fed excess dietary glucose reduce insulin-1 (INS-1) expression specifically in the BAG glutamatergic sensory neurons. We demonstrate that INS-1 expression in the BAG neurons is directly controlled by the transcription factor ETS-5, which is also down-regulated by glucose. We further find that INS-1 acts exclusively from the BAG neurons, and not other INS-1-expressing neurons, to systemically inhibit fat storage via the insulin-like receptor DAF-2. Together, these findings reveal an intertissue regulatory pathway where regulation of insulin expression in a specific neuron controls systemic metabolism in response to excess dietary glucose. |
| Volume | 20(5) |
| Pages | e3001655 |
| Published | 2022-5-1 |
| DOI | 10.1371/journal.pbio.3001655 |
| PII | PBIOLOGY-D-21-02978 |
| PMID | 35594303 |
| PMC | PMC9162364 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Diet Forkhead Transcription Factors / metabolism Glucose / metabolism Insulin* / metabolism Neurons / metabolism Receptor, Insulin / genetics Receptor, Insulin / metabolism |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 26 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm1734 tm1888 |