| RRC ID |
76189
|
| 著者 |
Hendi A, Niu LG, Snow AW, Ikegami R, Wang ZW, Mizumoto K.
|
| タイトル |
Channel-independent function of UNC-9/Innexin in spatial arrangement of GABAergic synapses in C. elegans.
|
| ジャーナル |
Elife
|
| Abstract |
Precise synaptic connection of neurons with their targets is essential for the proper functioning of the nervous system. A plethora of signaling pathways act in concert to mediate the precise spatial arrangement of synaptic connections. Here we show a novel role for a gap junction protein in controlling tiled synaptic arrangement in the GABAergic motor neurons in Caenorhabditis elegans, in which their axons and synapses overlap minimally with their neighboring neurons within the same class. We found that while EGL-20/Wnt controls axonal tiling, their presynaptic tiling is mediated by a gap junction protein UNC-9/Innexin, that is localized at the presynaptic tiling border between neighboring dorsal D-type GABAergic motor neurons. Strikingly, the gap junction channel activity of UNC-9 is dispensable for its function in controlling tiled presynaptic patterning. While gap junctions are crucial for the proper functioning of the nervous system as channels, our finding uncovered the novel channel-independent role of UNC-9 in synapse patterning.
|
| 巻・号 |
11
|
| 公開日 |
2022-11-15
|
| DOI |
10.7554/eLife.80555
|
| PII |
80555
|
| PMID |
36378164
|
| PMC |
PMC9665852
|
| MeSH |
Animals
Caenorhabditis elegans* / physiology
Caenorhabditis elegans Proteins* / genetics
Caenorhabditis elegans Proteins* / metabolism
Connexins / genetics
Connexins / metabolism
Membrane Proteins / genetics
Membrane Proteins / metabolism
Motor Neurons / metabolism
Synapses / metabolism
|
| リソース情報 |
| 線虫 |
tm5479
tm4133 |
