論文 - 詳細
| RRC ID | 76199 |
|---|---|
| 著者 | Jiang J, Su Y, Zhang R, Li H, Tao L, Liu Q. |
| タイトル | C. elegans enteric motor neurons fire synchronized action potentials underlying the defecation motor program. |
| ジャーナル | Nat Commun |
| Abstract |
C. elegans neurons were thought to be non-spiking until our recent discovery of action potentials in the sensory neuron AWA; however, the extent to which the C. elegans nervous system relies on analog or digital coding is unclear. Here we show that the enteric motor neurons AVL and DVB fire synchronous all-or-none calcium-mediated action potentials following the intestinal pacemaker during the rhythmic C. elegans defecation behavior. AVL fires unusual compound action potentials with each depolarizing calcium spike mediated by UNC-2 followed by a hyperpolarizing potassium spike mediated by a repolarization-activated potassium channel EXP-2. Simultaneous behavior tracking and imaging in free-moving animals suggest that action potentials initiated in AVL propagate along its axon to activate precisely timed DVB action potentials through the INX-1 gap junction. This work identifies a novel circuit of spiking neurons in C. elegans that uses digital coding for long-distance communication and temporal synchronization underlying reliable behavioral rhythm. |
| 巻・号 | 13(1) |
| ページ | 2783 |
| 公開日 | 2022-5-19 |
| DOI | 10.1038/s41467-022-30452-y |
| PII | 10.1038/s41467-022-30452-y |
| PMID | 35589790 |
| PMC | PMC9120479 |
| MeSH | Action Potentials / physiology Animals Caenorhabditis elegans* / physiology Caenorhabditis elegans Proteins* Defecation / physiology Motor Neurons / physiology |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 28 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3524 |